Collagen biostimulators
Biostimulators are injectable substances that stimulate the skin to produce new collagen. The most widely used are poly-L-lactic acid (Sculptra) and calcium hydroxylapatite (Radiesse), used for mild to moderate laxity of the face, neck and body. Polynucleotides improve hydration and the quality of thin skin, such as the skin under the eyes.
Summary
- Procedure
- 30 to 45 minutes, with local anesthetic
- Number of sessions
- Usually 2 to 3, 30 to 60 days apart
- Result
- Gradual, starting at 2 to 3 months
- Maintenance
- Yearly for biostimulators, and 2 to 3 sessions a year for polynucleotides
- Recovery
- Mild swelling and bruising for 2 to 5 days
Who it is for
For people who notice thinner, less firm skin, with early laxity on the face, neck, chest or arms. Biostimulators act slowly, so they suit people who prefer gradual change. Pregnancy, breastfeeding, active infection and some autoimmune diseases are contraindications.
How it works
The product is diluted and injected with a cannula or needle into the deep layers of the skin. After poly-L-lactic acid, the area should be massaged for a few days, following the written instructions Dr. Karen von Kossel gives you. The response depends on each person's age and skin, and new collagen takes months to form.
Aftercare
Avoid intense exercise, saunas and heat exposure for 24 hours. Small lumps under the skin can appear and should be shown at the follow-up visit.
Frequently asked questions
Do biostimulators add volume like fillers?
The effect is different. A biostimulator triggers collagen production and gradually improves skin firmness and thickness. Hyaluronic acid fillers add volume the same day.
How long do results last?
The collagen formed usually lasts 18 to 24 months, fading gradually. That is why maintenance is usually yearly.
Last updated November 10, 2026 · Medical director (responsável técnica): Dr. Karen von Kossel, CRM-SP 107714 · RQE 58534